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Updated: Jun 17, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
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In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

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在晚期尤文肉瘤患者中使用雷戈拉费尼布:非比较性,随机,双盲,安慰剂控制,多中心II期研究的结果

Florence Duffaud1, Jean-Yves Blay2, Axel Le Cesne3

  • 1APHM Hopital La Timone, Medical Oncology Unit, and Aix-Marseille University (AMU), Marseille, France. florence.duffaud@ap-hm.fr.

British journal of cancer
|November 2, 2023
PubMed
概括

在标准治疗后复发Ewing肉瘤 (ES) 的患者中,regorafenib在延缓瘤进展方面显示出适度的益处. 虽然在统计学上没有显著性,但该药物为晚期骨癌提供了潜在的治疗选择.

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A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

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Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...