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438名新生儿的心电图学特征与心房 Septal 缺陷
Anna Maria Dehn1, Maria Munk Pærregaard2, Anna Sellmer3
1Department of Cardiothoracic Surgery, The Heart Center, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark. anna.maria.dehn@regionh.dk.
Pediatric cardiology
|November 2, 2023
概括
前庭隔膜缺陷 (ASD) 与新生儿早期心电图 (ECG) 变化有关. 在第一周内,P波持续时间和PR间隔差异出现,这表明ASD新生儿的心脏电活动发生变化.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 新生儿心电图学 新生儿心电图学
- 遗传性心脏病是一种先天性心脏病.
背景情况:
- 前庭隔膜缺陷 (ASD) 是一种常见的先天性心脏病.
- 在ASD患者中经常观察到心电图 (ECG) 异常.
- 这些新生儿心电图变化的时间和起源尚未完全理解.
研究的目的:
- 调查二次ASDs新生儿心电图异常的存在和特征.
- 为了确定心电图的变化是否从出生就存在,或者是由于血液动力学变化而发生的次要变化.
- 分析新生儿患有自闭症的ECG发现与检查时的年龄之间的关联.
主要方法:
- 来自哥本哈根婴儿心脏研究的回声心电图和心电图的分析,这是一个基于人口的队列.
- 在438名患有第二次ASD的新生儿和1314名匹配的对照人群之间比较ECG特征.
- 根据检查时的年龄进行子组分析 (第一周与2-4周).
主要成果:
- 与对照组相比,患有自闭症的新生儿表现出较长的P波持续时间 (58比56毫秒) 和PR间隔 (100比96毫秒) (p < 0.001).
- 在患有自闭症的新生儿中观察到更向右移动的QRS轴 (116比114度,p=0.032).
- 在生命的第一个星期,P波持续时间和PR间隔差异显而易见;QRS轴差异在2-4周后出现.
结论:
- 前庭隔膜缺陷与可从新生儿时期检测到的明显的心电图变化有关.
- 在患有自闭症的新生儿中,延长的P波持续时间和PR间隔表明心脏电活动发生变化,不仅仅是血液动力学的次要因素.
- 患有自闭症的新生儿的心电图监测可以揭示心脏电气变化的早期迹象.
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