基于石的疗法:接受胃绕道手术的肥胖患者的新疗法?
Cerqueira Rute Maria1, Correia Manuel Rodriguez2, Pita Ines2
1Serviço de Gastrenterologia, Centro Hospitalar Entre Douro E Vouga, R Dr. Cândido Pinho, 4520-271, Santa Maria Feira, Portugal. rcerqueira@chedv.min-saude.pt.
Obesity surgery
|November 2, 2023
概括
在接受胃绕道手术的肥胖患者中,石四重疗法 (BQT) 有效地根除了Helicobacter pylori (Hp). 这种一线治疗实现了高根除率,在这个人群中证明了HP治疗的可靠性.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 手术瘤学手术瘤学
背景情况:
- 肥胖是一个日益严重的全球健康问题.
- 路克斯-en-Y胃绕道手术是一种常见的减肥手术.
- 杆菌 (Hp) 感染很普遍,并与各种胃肠道疾病有关.
研究的目的:
- 评估作为HP感染的第一线治疗方法,木四重疗法 (BQT) 的疗效.
- 在接受Roux-en-Y胃绕道手术的肥胖患者中评估HP根除率.
- 确定BQT是否符合马斯特里赫特V/佛罗伦萨共识指南,用于在高克拉里素耐药性地区的HP根除.
主要方法:
- 一个单一中心前性研究进行了3年.
- 基线内镜和HP评估通过组织学.
- 治疗后的HP状态通过C13尿素呼吸试验确认,治疗结束后4-6周.
- 使用IBM SPSS统计数据进行分析,并进行非参数比较.
主要成果:
- 这项研究包括598名肥胖的hp阳性患者 (78.6%为女性,平均年龄为43.2岁).
- 在500名患者中成功实现了HP根除,导致根除率为83.6% (95%CI:80.4%-86.5%).
- 根除率没有受到性别,年龄,内镜检查结果或吸烟状况的显著影响 (p > 0.05).
结论:
- 十天的BQT实现了马斯特里赫特V/佛罗伦萨建议的葡萄牙肥胖患者至少80%的第一线根除率.
- 在这个特定的患者群体中,BQT被证明是第一线HP根除的可靠选择.
- 这些发现支持BQT作为在接受胃绕道手术的肥胖个体中对HP感染的高度有效的治疗策略.
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