过度娱乐性氧化使用的神经并发症:基于文本挖掘算法的案例系列
B J Ruijter1, M J de Mooij2, J E Bruijnes3,4
1Department of Neurology, OLVG, Amsterdam, the Netherlands. b.j.ruijter@olvg.nl.
Journal of neurology
|November 2, 2023
概括
娱乐性氧化 (N2O) 的使用与严重的神经问题如多神经病变和骨髓病变有关. 及时的维生素B12检测和补充对于管理过度使用者的这些并发症至关重要.
科学领域:
- 神经学 神经学
- 毒理学 毒理学 毒理学
- 营养神经科学 营养神经科学
背景情况:
- 娱乐用氧化 (N2O) 的使用量增加,导致潜在的神经复杂症.
- 这项研究调查了过度N2O消费的个体的神经损伤.
研究的目的:
- 描述与娱乐性氧化 (N2O) 滥用相关的神经并发症.
- 评估N2O诱导的神经损伤的诊断方法和治疗结果.
主要方法:
- 一项回顾性,三中心研究利用文本挖掘来识别娱乐性N2O使用和神经症状的患者.
- 分析患者数据,包括临床诊断,维生素B12状态,MRI发现和电肌图结果.
主要成果:
- 确定了251名过度N2O使用者,常见的诊断包括多神经病 (78%),骨髓病 (41%) 和脑病 (14%).
- 在90%的病例中,维生素B12缺乏指标异常;MRI和电肌图分别显示骨髓病变和多神经病变的诊断价值有限.
- 用维生素B12补充剂治疗导致79%的患者在适当的随访后部分或完全康复.
结论:
- 过度的休性氧化 (N2O) 使用与神经系统缺陷的高患病率有关,特别是多神经病和骨髓病.
- 逐步测试维生素B12,同型半氨酸和甲基马龙酸水平有助于诊断,而MRI和EMG的实用性有限.
- 有效的管理包括维生素B12补充剂和N2O滥用的复发预防策略.
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