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可注射组织假体用于瞬间闭环康复

Subin Jin^1,2, Heewon Choi^2,3, Duhwan Seong^2,3

¹Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea.

|November 2, 2023

概括

研究人员开发了一种可注射的水凝假体,可用于神经肌肉的双向电导. 这种新材料支持机器人辅助的康复,

科学领域:

生物材料科学
复原医学
神经假肢

背景情况:

软的电活性水凝为类似组织的假肢材料提供了有前途的性能,包括合适的机械模量和电导率.
目前的生物电子假肢设备通常是贴片型,限制它们在不规则或深层组织表面的应用.

研究的目的:

为神经肌肉应用开发可注射的双向导电组织假体.
克服当前贴片式生物电子设备的局限性.

主要方法:

使用双键和黄金纳米粒子与酸介导的交联制造生物相容的水凝.
通过交叉合反应在现场形成导电性黄金纳米粒子.
在严重肌肉损伤的老鼠中进行闭环机器人辅助康复的演示.

主要成果:

可以注射的假肢在神经肌肉系统中显示了瞬间的双向电导.
在动物模型中成功使用注射材料进行闭环机器人辅助康复.
在肌肉损伤后期加速组织修复的证据.

结论:

这种新型的可注射水凝假肢为神经肌肉应用提供了新的解决方案,克服了现有的贴片类型设备的局限性.
这种材料有助于有效的机器人辅助康复,并促进组织再生.

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