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对高血压儿童和青少年内皮功能障碍的评估
Kenan Doğan1, Eviç Zeynep Başar2, Mehmet Baha Aytaç3
1Department of Pediatric Nephrology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. drdogankenan@gmail.com.
Pediatric nephrology (Berlin, Germany)
|November 2, 2023
概括
刚诊断出高血压的儿童表现出内皮功能障碍的早期迹象,包括动脉内膜介质厚度增加和流媒体扩张减少. 这些血管变化凸显了儿童群体早期高血压检测和管理的必要性.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 血管生物学 血管生物学
- 高血压研究 高血压研究
背景情况:
- 儿童的高血压可能会导致由于内皮损伤导致早期动脉样硬化变化.
- 内皮功能障碍是血管并发症发展的关键因素.
- 早期发现儿童的高血压对于预防长期心血管问题至关重要.
研究的目的:
- 研究新诊断的儿童内皮功能障碍和高血压之间的关系.
- 评估动脉内膜介质厚度 (CIMT),流媒体扩张 (FMD) 和功能性毛细血管镜在没有末端器官损伤的高血压儿童中.
- 为了比较Diper和非Diper高血压患者之间的血管参数.
主要方法:
- 一项涉及20名新诊断高血压儿童和20名年龄/性别匹配的健康对照者的横截面研究.
- 测量包括CIMT,手臂动脉口腔炎,以及在抗高血压治疗前进行的功能毛细管镜检查.
- 高血压患者被分为滴水和非滴水组.
主要成果:
- 与对照组相比,高血压儿童的CIMT显著增加,手臂动脉口腔炎减少,功能毛细血管密度较低.
- 在CIMT (p=0.04),口炎 (p=0.02) 和毛细血管密度 (p<0.001) 中观察到显著差异.
- 在滴滴高血压儿童和非滴滴高血压儿童之间没有发现血管参数的显著差异.
结论:
- 没有目标器官损伤的新诊断的高血压儿童显示出显著的内皮细胞变化.
- 这些发现强调了儿童早期高血压检测和管理的重要性.
- 对CIMT,口病和毛细管透视的分析可以确定儿科高血压的早期血管后果.
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