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DNA损伤反应 (DDR):细胞衰老与人类细胞巨乳病毒之间的联系
Xinna Wu1, Xuqiang Zhou2, Sanying Wang3
1Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou, 310030, China.
Virology journal
|November 2, 2023
概括
DNA损伤反应 (DDR) 对人类细胞巨核病毒 (HCMV) 复制和病毒诱导衰老 (VIS) 至关重要. 本综述探讨了DDR,衰老和HCMV之间的相互作用,并提供了对VIS机制的见解.
科学领域:
- 分子生物学分子生物学
- 病毒学 病毒学
- 细胞生物学 细胞生物学
背景情况:
- DNA损伤反应 (DDR) 是DNA损伤激活的关键细胞通路,导致细胞循环停止和DNA修复.
- 细胞衰老是一种不可逆转的细胞周期停止状态,通常伴随着衰老相关的分泌表型 (SASP),涉及炎症性细胞因子释放.
- 人类细胞巨核病毒 (HCMV) 是一种常见的病原体,涉及到细胞衰老过程.
研究的目的:
- 审查DNA损伤反应 (DDR),细胞衰老和人类细胞巨乳病毒 (HCMV) 感染之间的复杂关系.
- 为病毒诱导的衰老 (VIS) 提供新的视角,由HCMV驱动.
主要方法:
- 文献综述综合了关于DDR,衰老和HCMV的现有研究.
- 对将DDR激活与HCMV复制和衰老诱导联系起来的分子机制的分析.
- 探索DDR在病毒诱导衰老的建立和特征中的作用.
主要成果:
- DDR对于高效的HCMV复制是必不可少的,表明病毒对宿主细胞DNA修复途径的依赖.
- 冠状病毒感染可以触发或调节DDR信号,从而导致细胞衰老.
- DDR和HCMV之间的相互作用影响着老化相关分泌表型 (SASP) 的发展.
结论:
- DNA损伤反应 (DDR) 是HCMV复制和诱导细胞衰老的关键因素.
- 了解DDR-HCMV衰老轴为病毒诱导衰老 (VIS) 提供了新的见解.
- 本综述强调了DDR途径中的潜在治疗点,用于管理HCMV感染和相关病理.
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