慢性免疫媒介炎症疾病患者的COVID-19疫苗接种
Wen Yanfang1, Chen Jianfeng2, Liu Changlian3
1Department of Rheumatology, Changsha Hospital of Traditional Chinese Medicine, Changsha, China. wenyanfang1984@aliyun.com.
Advances in rheumatology (London, England)
|November 2, 2023
概括
对于患有免疫媒介炎症疾病 (IMID) 的患者来说,COVID-19疫苗接种是安全有效的. 研究显示轻微的副作用和疾病活性的没有增加,证实了疫苗在这个人群中的有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 慢性免疫媒介性炎症性疾病 (IMID) 影响免疫系统调节.
- 在IMID患者中评估COVID-19疫苗的安全性和有效性至关重要.
- 了解免疫受损人群的疫苗反应是公共卫生的优先事项.
研究的目的:
- 评估COVID-19疫苗在中国慢性IMID患者中的安全性和有效性.
- 为了比较IMID患者和健康对照之间的不良事件,IMID活动和COVID-19发病率.
- 为了确定COVID-19疫苗接种是否影响IMID患者的疾病活性.
主要方法:
- 一项包括158名慢性IMID患者和153名中国健康对照者的队列研究.
- 参与者接受了两剂不活化的CoronaVac或三剂复合蛋白亚单元ZF2001疫苗.
- 与疫苗相关的不良事件,疫苗接种后的IMID活动和COVID-19发病率的比较.
主要成果:
- 与对照组相比,IMID组的疫苗相关不良事件较少,所有事件都是轻微和局部的.
- 在接种疫苗后的IMID组中没有观察到严重的不良事件或疾病爆发.
- 在IMID和对照组中,COVID-19发病率为0%,表明疫苗的疗效.
结论:
- 对于患有慢性IMID的患者来说,COVID-19疫苗接种是安全的,疾病活动没有增加.
- 疫苗接种有效地减少了IMID患者中COVID-19的发生率.
- 建议使用更大的样本大小和更长的随访期进行进一步的研究.
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