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刺激响应纳米技术用于RNA传递

Hui Zhou^1,2,3, Dean Shuailin Chen², Caleb J Hu²

¹Department of Cardiology, Clinical Trial Center, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|November 2, 2023

概括

刺激响应纳米技术通过保护RNA,改善细胞吸收,并使向输送成为可能,从而增强RNA药物输送. 这些先进的纳米粒子为下一代RNA药物提供了一个有希望的途径.

科学领域:

生物技术和纳米医学
分子生物学和治疗学

背景情况:

核糖核酸 (RNA) 药物通过调节基因表达和蛋白质合成来提供治疗潜力.
RNA药物的成功临床转化,包括小干扰RNA (siRNA) 和信使RNA (mRNA) 疗法,依赖于化学修饰,配体结合和纳米技术等策略.
纳米技术在保护RNA免受降解,增强细胞吸收和运输,延长血液循环和改善向方面发挥着至关重要的作用.

研究的目的:

为RNA传递提供对刺激反应纳米技术的专注概述.
突出这些纳米技术在促进RNA生物活性和细胞/器官选择性方面的独特好处.
总结各种刺激响应的纳米粒子系统用于RNA输送,以促进下一代RNA药物的开发.

主要方法:

对利用微环境特征 (如pH,酶,缺氧和氧化还原) 的内部刺激响应RNA纳米粒子 (NP) 的审查.
对利用光,磁场和超声波来控制RNA释放和运输的外部刺激响应系统的审查.
对广泛的刺激响应NP系统进行RNA传递信息的综合.

主要成果:

刺激响应纳米技术在提高RNA药物疗效和特异性方面具有独特的优势.
对内部刺激有反应的NP利用特定的生物线索来进行有针对性的输送和释放.
外部刺激响应系统可以精确控制RNA递送动力学和生物分布.

结论:

刺激响应纳米技术对于通过改善输送和向来推进RNA医学至关重要.
内部和外部刺激反应策略的整合为开发高效和选择性RNA疗法具有重大潜力.
本综述提供了当前方法的全面总结,为未来RNA药物输送创新铺平了道路.

关键词:

配送RNA配送RNA的时间基因沉默是对基因进行沉默的方法.基因组编辑基因组编辑纳米技术是纳米技术.蛋白质表达蛋白质表达刺激-响应的刺激.

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