一终身的嗅觉剥夺依赖于皮质重组,仅限于轨道前皮层
Moa G Peter1, Fahimeh Darki1, Evelina Thunell1
1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Human brain mapping
|November 2, 2023
概括
患有先天性厌氧症 (CA) 的个体表现出正常的皮质皮层形态,尽管终身缺少嗅觉. 在CA中,大脑的变化仅限于轨道前皮层 (OFC),这挑战了以前的感官剥夺理论.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 人类解剖学 人类解剖学
背景情况:
- 长时间的感官剥夺与皮层重组有关.
- 先天性厌氧症 (CA) 涉及终身的嗅觉剥夺.
- 以前关于CA大脑形态的研究结果是矛盾的.
研究的目的:
- 复制和验证以前关于CA患者大脑形态学的研究结果.
- 调查CA中皮质状皮质和轨道前皮质 (OFC) 中的皮质重组.
- 为了确定CA的形态偏差是否仅限于OFC.
主要方法:
- 使用基于voxel和表面的形态学直接复制.
- 与CA (n=30) 和年龄/性别匹配的对照组 (n=30) 的个人进行比较.
- 综合数据的多变量分析 (支向量机器分类) (CA=49,控制=49).
主要成果:
- 复制证实了CA的双边OFC差异,包括缩和体积增加.
- 在皮质皮质 (嗅觉皮质) 中没有发现显著的群体差异.
- 多变量分析准确地区分了OFC中的群体,但不是皮质状皮质.
结论:
- 皮形皮质在CA个体中在形态上保持不变,尽管终身缺少嗅觉.
- 与CA相关的形态偏差特别局限于轨道前皮层 (OFC).
- 研究结果表明,在先天性厌氧症中,大脑适应的一个独特模式,与其他感官剥夺模型不同.
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