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在尤文肉瘤免疫微环境中,中性粒细胞外细胞陷形成的建议作用

Rachel Shukrun^1,2,3, Szilvia Baron^1,3, Victoria Fidel¹

¹Pediatric Hemato-Oncology Research Laboratory, Tel Aviv Medical Center, Tel Aviv, Israel.

|November 2, 2023

概括

中性细胞细胞外陷 (NETs) 在尤文肉瘤 (EWS) 患者中升高,特别是转移性疾病患者. 高的NET形成预测化学疗法反应和生存率不佳,这表明NET作为治疗点.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

尤文肉瘤 (EWS) 是一种具有不良转移性疾病生存率的侵袭性癌症.
中性粒细胞外细胞陷 (NETs) 是中性粒细胞释放的DNA结构,但它们在EWS中的作用尚不清楚.

研究的目的:

研究EWS患者瘤透性中性粒细胞 (TINs) 和NETs的存在和预后意义.
评估外周血液中的NET及其与临床特征和治疗反应的相关性.

主要方法:

用免疫光学分析46名EWS患者的TIN和NET诊断活检分析.
在诊断和化疗后对外围血液中性粒细胞中NET的研究.
NET存在与临床病理特征和患者结果的相关性.

主要成果:

与局部疾病相比,在转移性EWS中观察到TIN和NET的较高水平.
诊断时NET形成升高预测化学疗法反应不佳,复发和死亡率.
周围血液NET在EWS患者中明显高于对照组,并在化疗后降低.

结论:

网络形成在EWS免疫微环境中起作用.
网络可以作为风险分层和预测EWS治疗耐药性的生物标志物.
准NET可能为EWS提供一种新的治疗策略.

关键词:

尤文肉瘤 (Ewing Sarcoma) 是一种癌症.作为一个中性恋者.中性粒细胞外细胞陷 (NETs)预后预后预后瘤微环境是一个微环境.

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