在部超声波上区分病态副甲状腺和甲状腺结节:PARATH-US横截面研究
Dolly Yazgi1, Carine Richa1, Sylvie Salenave1
1Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d'Endocrinologie et des Maladies de la Reproduction, Le Kremlin-Bicêtre, France.
The Lancet regional health. Europe
|November 2, 2023
概括
部超声波可以区分病态副甲状腺 (PPG) 和甲状腺结节,使用独特的美国特征. PPG可能呈现为高风险病变,需要评估水平以防止不必要的程序.
科学领域:
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 部超声波 (美国) 对于鉴定甲状腺结节和病理性副甲状腺 (PPG) 的特征至关重要.
- 使用US区分甲状腺结节和PPG可能具有挑战性.
- 目前没有任何研究直接比较这两种常见的部瘤的美国特征.
研究的目的:
- 确定美国独特的特征,将PPG与甲状腺结节区分开来.
- 为了比较PPG和甲状腺结节的美国特征.
- 评估美国特征在甲状腺恶性瘤风险分层系统中对PPG进行分类时的潜力.
主要方法:
- 一个单中心的研究在第三级推中心.
- 176个PPG与232个大小和体积相匹配的甲状腺结节进行了比较.
- 对形态模式,回声含量和血管状况的分析.
主要成果:
- 在PPG和甲状腺瘤之间观察到形态模式,回声含量和血管状况的显著差异 (p < 0.01).
- 结合了美国的参数,从甲状腺结节中最大限度地区分了PPG (OR,7.6;p < 0.0001).
- 使用甲状腺恶性瘤风险分层系统,58-63%的PPG被归类为高风险病变. 副甲状腺瘤大于过度增生 (p=0.013).
- 血清和PTH水平与PPG大小和体积有很强的相关性 (p < 0.0001).
结论:
- 独特的美国特征有效地区分PPG与甲状腺结节.
- PPG可以表现出高风险的美国特征,模仿甲状腺结节.
- 怀疑PPG和评估高风险宫病变中的水平可以防止不必要的侵入性手术.
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