口服万科米辛治疗抑制了肠道素活性,并在EAE期间保持了肠道屏障功能
Paola Bianchimano1,2,3, Kacper Iwanowski1,2,3, Emma M Smith1,2,3
1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
iScience
|November 2, 2023
概括
在多发性硬化症模型中,万科米辛治疗改善了肠道屏障的完整性,并通过抑制肠道素活性和增加有益的乳酸菌来降低疾病的严重程度. 这表明肠道素,肠道透性和神经炎症之间存在联系.
科学领域:
- 神经免疫学 神经免疫学
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 在多发性硬化症 (MS) 和其动物模型实验性自身免疫脑膜炎 (EAE) 中观察到肠道透性增加.
- 关联肠道屏障功能障碍与EAE中神经炎症的确切机制在很大程度上是未知的.
研究的目的:
- 研究肠道素活性和肠道透性在EAE期间调节神经炎症中的作用.
- 探索万科米辛在维护肠道屏障完整性和改善EAE方面的治疗潜力.
主要方法:
- 给EAE小鼠服用万科米辛,以评估其对肠道屏障完整性,肠道素活性和肠道微生物群组成的影响.
- 乳杆菌丰富度,肠道素活性和EAE严重程度之间的相关性分析.
- 在EAE小鼠中测量肠道透性和蛋白酶激活受体2 (PAR2) 表达.
主要成果:
- 范科米辛治疗保留了肠道屏障的完整性,降低了肠道素活性,并增加了特定的乳球菌种的丰富性.
- 在接受万科米辛治疗的小鼠中,乳酸菌的丰富与肠道素活性和EAE严重程度有负相关性.
- 未经治疗的EAE小鼠表现出增加的肠道透性和增加的PAR2表达,这表明素-PAR2通路参与.
结论:
- 在肠道中肠道素和PAR2之间的相互作用似乎是影响肠道透性和EAE严重性的关键因素.
- 向肠道素活性和调节肠道微生物群可能是MS的一种有前途的治疗策略.
更多相关视频
10:50Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
7.7K
06:57Author Spotlight: Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis
Published on: May 12, 2023
2.3K
相关概念视频
01:18Surface Membrane Barriers
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
01:23Inhibitors of Gram-positive Cell Wall Synthesis
Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...