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剖析每日食模式:外围时钟/循环产生食/禁食的情节和神经元分子时钟同步他们

Akiko Maruko¹, Koichi M Iijima^2,3, Kanae Ando⁴

¹Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA.

|November 2, 2023

概括

草的每日食节奏由代谢组织中的准模态 (qsm) 和时钟 (CLK) 调节,独立于分子时钟机械,揭示了对食行为控制的新见解.

科学领域:

时间生物学时间生物学
昆虫生理学昆虫生理学
分子生物学分子生物学

背景情况:

一个24小时的食节奏对于生存至关重要,由内部时钟和光线调节.
产生日常养模式的精确分子机制尚未完全理解.
研究这些机制可以提供有关代谢调节和昼夜行为的见解.

研究的目的:

为了剖析Drosophila每日食模式的基础分子通路.
确定准模子 (qsm) 和时钟 (CLK) 在调节养节律中的作用.
为了阐明分子钟和养行为生成之间的相互作用.

主要方法:

在个体Drosophila中量化半日摄入的食物.
准相模 (qsm) 和 CLOCK (CLK) 基因功能的遗传分析.
在光下的行为测试:黑暗和持续的黑暗条件.

主要成果:

照明下的食节奏:在黑暗条件下需要准模态 (qsm),但不是核心分子时钟.
在持续的黑暗中,食节奏有两个组成部分:消化/代谢组织中的钟 (CLK) 和神经元分子钟.
代谢组织中的CLOCK (CLK) 产生了独立于分子时钟机械的食/禁食期.

结论:

夸西莫多 (qsm) 在产生Drosophila的食节奏方面发挥着关键作用.
在消化和代谢组织中,CLK独立地驱动食/禁食期.
这些发现揭示了qsm和CLK在调节养行为和昼夜节律方面的新功能.

关键词:

细胞神经科学细胞神经科学分子神经科学分子神经科学

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