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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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在非透析CKD患者心血管结果中是否存在性别差异?
Pasquale Fabio Provenzano1, Grazia Caridi2, Giovanna Parlongo2
1CNR-IFC, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy.
Clinical kidney journal
|November 2, 2023
概括
患有慢性病 (CKD) 的男性患者患心血管事件的风险更高. 这种风险随着年龄的增长而增加,强调性别和年龄是CKD心血管结果的关键因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 在非透析慢性病 (CKD) 患者中调查心血管 (CV) 风险和结果的性别差异至关重要,因为之前的研究有限.
- 这项研究通过检查意大利南部的CKD阶段2-5患者队列来弥补这一差距.
研究的目的:
- 确定性别和致命和非致命主要心血管事件发生率在CKD患者之间的关系.
- 探索年龄对这一群体性别和心血管结果之间的关联的影响.
主要方法:
- 一组759名患有CKD2-5阶段的患者被跟踪了36个月的中位数.
- 使用考克斯回归分析来评估性别与主要心血管事件之间的关联,并对潜在的混因素进行调整.
- 进行了相互作用分析,以评估年龄作为改变性-CV事件关系的变量的影响.
主要成果:
- 男性的性别与重大心血管事件的更高发病率有显著的关联 (HR 1.75,95% CI 1.18-2.60),即使经过对混因素的调整 (HR 1.78,95% CI 1.03-3.09).
- 全因死亡率与男性性别没有显著的关联.
- 年龄显示出显著的效果修改 (P = .037),与女性相比,男性的CV事件的风险随着年龄的增长而逐渐增加.
结论:
- 与女性患者相比,患有CKD G2-5阶段的男性患者患心血管事件的风险较高.
- 年龄作为一个显著的风险改变因素,在广泛的年龄范围内的CKD患者中放大与男性性别相关的心血管风险.
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