贾菲和酶方法之间的血清肌素差异对病检测和分期的影响
Kristina Boss1, Susanne Stolpe2, André Müller3
1Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Clinical kidney journal
|November 2, 2023
概括
测量血清肌素 (SCr) 影响功能评估的不同方法. 与酶性SCr方法相比,Jaffe方法往往导致更严重的慢性病 (CKD) 阶段.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床化学 临床化学
- 生物标志物 生物标志物
背景情况:
- 血清肌素 (SCr) 是功能的一个关键指标.
- 使用Jaffe或酶方法测量SCr.
- 测量SCr方法之间的差异可能会影响急性损伤 (AKI) 和慢性病 (CKD) 的诊断.
研究的目的:
- 评估不同SCr测量方法对功能评估的影响.
- 为了比较来自Jaffe和酶方法的SCr结果.
- 确定SCr方法变化的临床意义,用于诊断和分期病.
主要方法:
- 从成年患者的41,144个并行SCr测量 (Jaffe和酶) 的回顾性分析 (2020-2022年).
- 使用Bland-Altman图表来评估Jaffe和酶性SCr (eSCr) 方法之间的一致性.
- 使用CKD-EPI 2009方程计算估计的膜过率 (eGFR).
主要成果:
- 平均而言,贾菲SCr比eScr高0.07毫克/分升.
- 在19%的病例中,CKD阶段发生了显著的差异,在98%的病例中,Jaffe SCr导致了更严重的阶段.
- 在1.6%的测量中,Jaffe SCr比eSCr高≥0.3 mg/dL.
结论:
- 测量SCr的方法显著影响AKI和CKD的诊断和分期.
- 在解释功能时,临床实践应考虑SCr方法的变化.
- 建议在SCr测量方法中保持一致性,最好是酶化,以确保可靠的患者管理和研究.
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