功能与糖尿病患者的足部风险高度相关
Jean-Baptiste Bonnet1,2, Ilan Szwarc3, Antoine Avignon1,2
1Diabetes-Nutrition Department, University Hospital of Montpellier, Montpellier, France.
Clinical kidney journal
|November 2, 2023
概括
慢性病 (CKD) 与糖尿病足 (DFU) 的风险有关. 较低的估计淋巴膜过率 (eGFR) 水平与较高的DFU风险阶段相关,特别是在EGFR低于45mL/min/1.73m2的患者中.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 糖尿病学 糖尿病学
- 足部医学是一门专业.
背景情况:
- 糖尿病足 (DFU) 是糖尿病的一个重要并发症.
- 慢性病 (CKD) 是一种已知的并发症,与DFU的发病率增加有关.
- 国际糖尿病足工作组 (IWGDF) 提供了DFU风险因素的分类系统.
研究的目的:
- 调查IWGDF DFU风险分类与糖尿病患者估计的淋巴细胞过率 (eGFR) 水平之间的关联.
- 为了探索这种关系,特别是在非透析的CKD患者中.
- 确定导致糖尿病患者群体中足部风险的因素.
主要方法:
- 一项前性多中心研究,涉及糖尿病学和病学部门的患者.
- 数据收集包括患者人口统计,糖尿病持续时间,IWGDF风险分类和eGFR.
- 进行了统计分析,以评估eGFR和足部风险阶段之间的相关性,包括不包括透析患者的子组分析.
主要成果:
- 在EGFR水平和较高的IWGDF足部风险阶段 (≥2) 之间观察到显著的反相关性.
- 患有足部风险阶段≥2的患者与患有较低风险阶段 (36.8 vs 71.9 mL/min/1.73 m2) 的患者相比,平均eGFR显著降低.
- 45mL/min/1.73m2的eGFR切线被确定为较高的足部风险 (阶段≥2) 的歧视因素,AUC为0.76.
结论:
- 估计的淋巴膜过率 (eGFR) 水平与糖尿病患者的足部风险阶段有显著的关联.
- 糖尿病和慢性病患者,特别是那些EGFR<45mL/min/1.73m2或透析的患者,需要谨慎管理.
- 与专门的糖尿病脚中心的合作对于管理高风险的CKD患者至关重要,以防止DFU并发症.
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