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怀孕期间母亲的维生素D和婴儿的肠道微生物群:系统性审查
Roghayeh Molani-Gol1,2, Maryam Rafraf2
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Frontiers in pediatrics
|November 2, 2023
概括
母亲产前维生素D补充剂可能会影响婴儿肠道微生物组合. 需要进一步的研究来证实维生素D对婴儿肠道微生物群及其发展的影响.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 儿科 儿科 儿科
背景情况:
- 婴儿肠道微生物组对健康至关重要.
- 母亲因素显著影响婴儿肠道微生物群的组成.
- 维生素D对于各种身体功能至关重要.
研究的目的:
- 审查关于母亲产前维生素D补充剂与婴儿肠道微生物组组成之间的关联的现有文献.
- 总结目前关于怀孕期间维生素D摄入如何影响婴儿肠道微生物群的发展的知识.
主要方法:
- 在主要的科学数据库 (PubMed,Scopus,Web of Science等) 中进行了系统的文献搜索. ) 的情况.
- 该审查包括在2022年12月之前在没有日期限制的情况下以英语出版的研究.
- 符合条件的研究包括小鼠模型,随机临床试验和队列研究.
主要成果:
- 母亲的维生素D补充剂影响了小鼠的后代肠道微生物组合,增加了Bacteroides的丰富性.
- 队列研究表明,产前维生素D与婴儿肠道微生物组之间存在显著的关联.
- 一些临床试验表明,在子宫内维生素D水平会影响婴儿微生物殖民.
结论:
- 怀孕期间母亲补充维生素D与婴儿肠道微生物组的改变有关.
- 有证据表明,维生素D在塑造婴儿肠道微生物群方面可能发挥作用.
- 需要进行额外的研究来验证这些发现并阐明机制.
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