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麻症及其在老年慢性阻塞性肺病中的临床相关性:一个前性队列研究
1Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. jiaweijin@ccmu.edu.cn.
European review for medical and pharmacological sciences
|November 2, 2023
概括
肉症是一种肌肉损失的情况,在患有慢性阻塞性肺病 (COPD) 的老年患者中显著增加急性恶化的风险. 早期发现与FEV1,BMI和血红蛋白水平相关的麻症对于管理COPD结果至关重要.
科学领域:
- 老年病的医生 老年病的医生
- 肺部病理学 肺部病理学
- 肌肉生理学 肌肉生理学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一种进展性肺病,通常与肌肉衰竭有关.
- 随着年龄的增长,肌肉质量和力量的丧失,即萨尔科佩尼亚,越来越多地被认为是老年患者的并发症.
- 石病对老年COPD患者的临床特征和预后的影响仍然是一个需要进一步研究的领域.
研究的目的:
- 调查老年COPD患者的肉类和临床特征之间的关联.
- 评估萨科佩尼亚对该群体短期结果的影响,包括急性恶化和死亡率.
- 在COPD的老年人中识别缩症的危险因素.
主要方法:
- 120名老年COPD患者 (年龄大于60岁) 的队列被根据入院时的严重程度分为肉症和非肉症组.
- 分析了包括老年综合征,实验室值和身体组成在内的基线数据.
- 一年后的随访评估了临床特征,急性恶化和全因死亡率,使用门诊访问和电话随访. 用单变量,多变量和COX回归模型分析了风险因素和预后影响.
主要成果:
- 在52.5% (63/120) 的老年COPD患者中,诊断出了肉症.
- 与非sarcopenia组相比,sarcopenia组表现出较差的肺功能 (较低的FEV1),更严重的老年综合征 (睡眠病,虚弱),以及肌肉指标和身体组成的减少.
- 萨科佩尼亚与较低的FEV1,BMI和血红蛋白水平独立相关. 最重要的是,在随访期间,肉类显著增加了急性恶化的风险 (HR=2.4,p=0.048).
结论:
- 皮症是老年COPD患者中普遍存在的疾病,与更糟糕的临床特征和更差的结果有关.
- 在这种患者群体中,sarcopenia显著增加了急性恶化的风险.
- 建议对FEV1,BMI和血红蛋白进行监测,以便在老年COPD患者中早期识别和治疗.
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