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索特罗维马布在COVID-19的固体器官移植接受者身上:系统性审查和元分析

Behnam Amani¹, Rouhollah Shabestan², Kourosh Rajabkhah³

¹Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Korean journal of transplantation

|November 2, 2023

概括

索特罗维马布显著降低了COVID-19的固体器官移植接受者的死亡率,住院和ICU入院率. 这种抗病毒治疗也表现出了有利的安全性概况,观察到的不良事件较少.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
移植医学移植医学

背景情况:

固体器官移植接受者 (SOTRs) 面临着 COVID-19 的高度脆弱性,即使在接种疫苗后.
在这种免疫功能低下的人群中,研究有效的COVID-19治疗方法至关重要.

研究的目的:

评估索特罗维马布在SOTRs中治疗COVID-19的疗效和安全性.
通过元分析来综合当前的证据.

主要方法:

在主要数据库 (PubMed,Cochrane,Web of Science,medRxiv,Google Scholar) 进行了系统的文献搜索,截至2023年7月25日.
十项涉及1569名患者的研究被纳入了元分析.
评估了偏差风险,并使用综合元分析软件分析了数据.

主要成果:

与标准护理相比,Sotrovimab治疗与显著降低的死亡率 (OR 0.15),住院 (OR 0.35),ICU入院 (OR 0.16),需要氧气 (OR 0.22) 和机械通风 (OR 0.09) 相关.
在sotrovimab和其他治疗方法之间,没有发现住院或ICU入院率的显著差异.
与对照组相比,索特罗维马布的不良事件发生率 (OR 0.15) 较低.

结论:

索特罗维马布显示有可能改善COVID-19的SOTRs的临床结果.
需要进一步进行高质量的临床试验来验证这些发现并巩固治疗建议.

关键词:

在 COVID-19 疫情中,器官移植器官移植器官移植这就是SARS-CoV-2病毒.

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