脑卒中后疼痛的患病率,轨迹和预测因素:聚合临床试验数据集的回顾性分析
Myzoon Ali1,2, Holly Tibble3, Marian C Brady2
1Institute of Cardiovascular and Metabolic Health, University of Glasgow, United Kingdom (M.A., T.J.Q.).
Stroke
|November 2, 2023
概括
脑卒中后疼痛影响3-9.5%的人,随着依赖程度的增加而增加. 早期干预对于控制疼痛和改善中风后的结果至关重要.
科学领域:
- 神经学 神经学
- 疼痛医学 医学 疼痛医学
- 康复 康复 康复 康复
背景情况:
- 脑卒中后的疼痛经常被诊断不足,并没有得到适当的治疗.
- 了解疼痛的流行和轨迹是及时干预的关键.
研究的目的:
- 为了检查中风后疼痛的患病率,轨迹和相关参与因素.
- 为了告知最佳时间开始对中风后疼痛进行干预.
主要方法:
- 从虚拟国际中风试验档案 (VISTA) 中的10项研究中分析了个人参与者数据,其中包括超过10,000名参与者.
- 使用欧洲生活质量尺度 (EQ-5D-3L) 的标准化疼痛评估疼痛领域.
- 多变量模型评估了人口统计,疼痛,流动性,独立性,焦虑/抑郁,活力和中风严重程度之间的关联.
主要成果:
- 3%至9.5%的参与者报告了极度疼痛,在中风后的2年内达到顶峰.
- 较差的独立性与中风后多个时间点的疼痛的存在和严重程度显著相关.
- 焦虑/抑郁和活力下降也与疼痛严重程度的增加有关.
结论:
- 在3%至9.5%的人群中,有极度的中风后疼痛.
- 疼痛的存在和严重程度独立地与中风后的依赖有关.
- 需要进一步的研究来确定中风后疼痛干预措施的有效性和最佳时间.
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