DNA 损伤和动脉高血压. 一个系统的审查和元分析
Radka Hazukova1,2,3, Martina Rezacova4, Miloslav Pleskot3
1Department of Internal Medicine I - Cardiology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
概括
与健康对照组相比,高血压患者的氧化DNA损伤显著增加. 这一系统性审查强调了动脉高血压患者的DNA损伤标志物增加,强调了其临床相关性.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 生物化学 生物化学
背景情况:
- 氧化性DNA损伤标记物,包括8-基-2'-脱氧氨酸 (8OHdG),彗星测定和gammaH2AX,在临床心脏病学中越来越多地使用.
- 动脉高血压是心血管疾病的重要危险因素,其潜在机制正在持续调查中.
研究的目的:
- 对人类氧化DNA损伤和动脉高血压之间的关联进行系统审查和元分析.
- 与健康对照组相比,评估高血压患者的特定DNA损伤标志物的水平.
主要方法:
- 在PubMed和Web of Science上进行了全面的文献搜索,搜索到2022年6月30日之前发表的英语研究.
- 包括的研究集中在患有动脉高血压的人身上,不包括儿童,动物模型和细胞系. 分析了15项人类研究的数据,其中包括902名高血压患者和587名对照患者.
- 使用元分析来确认DNA损伤标记的发现 (彗星测定和8OHdG).
主要成果:
- 与健康对照组相比,高血压患者的DNA损伤水平明显高,通过彗星测定和8OHdG水平 (P<0.05) 测量.
- 在更严重的高血压病例中观察到较高的DNA损伤,包括集中性心脏缩,持续/未治疗的高血压,不下降的血压模式,老年人和冠状动脉心脏病患者 (P<0.05).
- DNA损伤与血清糖化血红蛋白 (r=0.670;P<0.05) 有着强烈的正相关性,与总抗氧化剂状况 (r=-0.670至-0.933;P<0.05) 有负相关性.
结论:
- 这一系统性审查和元分析提供了第一个全面的证据,证明氧化DNA损伤在患有动脉高血压的人群中显著增加.
- 这些发现表明,氧化DNA损伤是相关的生物标志物,并可能导致高血压的病理生理学及其心血管并发症.
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