上部泌尿道样本的细胞学评估:使用"巴黎报告尿细胞学系统"第二版的机构回顾性研究,并进行了病学后续检查
Ghazal Khajir1,2, Tong Sun1, He Wang1
1Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.
概括
巴黎尿路细胞病理报告系统 (TPS 2.0) 的性能与上尿路细胞学报告系统的性能相当. 然而,在UUT标本中诊断低度泌尿腺癌 (LGUC) 仍然具有挑战性.
科学领域:
- 尿路病理学 尿路病理学
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
背景情况:
- 上部泌尿道 (UUT) 的细胞学评估通常因仪器仪表而复杂化.
- 标准化报告系统对于准确和可重复的细胞病理诊断至关重要.
- 巴黎尿路细胞病理报告系统 (TPS) 旨在标准化尿路样本评估.
研究的目的:
- 用第二版"巴黎系统" (TPS 2.0) 来回顾UUT细胞学标本.
- 将TPS 2.0的诊断性能与原始报告系统 (ORS) 进行比较.
- 为了将细胞病理学发现与细胞病理学随访相关联.
主要方法:
- 对52个UUT细胞学标本的回顾性审查与组织病理学活检/切除相关.
- 使用TPS 2.0.0对标本进行盲目重新分类.
- 评估TPS 2.0,ORS和组织病理学之间的相关性.
主要成果:
- 组织病理学随访显示了40.4%的高度泌尿腺癌 (HGUC),51.9%的低度泌尿腺癌 (LGUC) 和7.7%的良性病例.
- 在分类高度恶性瘤风险方面,TPS 2.0和ORS表现相似.
- 大多数LGUC病例被两种系统分类为异型泌尿道细胞 (AUC) (55.6%对59.3%).
结论:
- 对于UUT细胞学标本,TPS 2.0的表现与ORS的表现相当.
- 对UUT标本的细胞学诊断,特别是LGUC,仍然具有挑战性.
- 对于像LGUC.这样具有挑战性的病例,可能需要进一步细化诊断标准.
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