新生儿重度甲状腺功能障碍症的外科治疗
Saud Alshanafey1, Sabreen Maqbol2, Ali AlAmeer2
1From the Department of Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Annals of Saudi medicine
|November 2, 2023
概括
手术有效地治疗新生儿严重甲状腺功能障碍症 (NSHPT). 虽然成像没有改变手术计划,但自体移植无法消除对终身和维生素D补充剂的需求.
科学领域:
- 内分泌学 在内分泌学.
- 儿科手术 儿科手术
- 遗传学 是一个遗传学.
背景情况:
- 新生儿严重甲状腺功能障碍 (NSHPT) 是一种罕见的,可能致命的内分泌疾病.
- 大多数被诊断为NSHPT的婴儿需要手术干预,特别是副甲状腺切除术.
- 由于NSHPT的严重程度,有效的管理策略至关重要.
研究的目的:
- 报告管理NSHPT的临床经验和结果.
- 评估手术治疗和自身移植的有效性.
- 分析手术前成像对手术规划的影响.
主要方法:
- 在2001年6月至2023年1月期间管理的19名NSHPT患者的回顾性图表审查.
- 收集的数据包括人口统计,临床表现,手术细节和后续情况.
- 术前和术后甲状腺激素 (PTH) 和水平被分析;进行遗传查.
主要成果:
- 19名患者 (13名男性,6名女性) 的平均转诊年龄为46天,接受了手术.
- 手术前平均PTH和水平为996ng/L和4.54mmol/L;16/19名患者患有感知的受体基因突变.
- 手术后的PTH和水平显著下降 (分别为25 ng/L和1.64 mmol/L),但所有患者都需要补充剂,除了两个自移植患者外.
结论:
- 手术治疗 (副甲状腺切除术) 是NSHPT的有效管理策略.
- 手术前的放射性定位研究 (超声波,Sestamibi扫描) 并没有影响治疗计划.
- 自体移植无效,使患者能够停止补充和维生素D.
更多相关视频
相关概念视频
00:59The Parathyroid Glands
2.1K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.1K
01:25Peptic Ulcer Disease V: Surgical Management and Nursing Care
314
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Surgical Interventions for Peptic Ulcer Disease
314
01:25Urinary Tract Calculi VI: Surgical Management
8
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
8
01:26Kidney Transplant II: Surgical Procedure
20
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
20
01:26Tonsillitis II: Management
120
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
120
01:30Urinary Tract Calculi III: Medical Management
9
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
9