含有的基酸联体的铜 (II) 复合物:合成,结构研究,溶液化学和与HSA的相互作用
Fagner da Silva Moura1, Ygor S Sobrinho1, Carolina Stellet1
1Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil. nicoarey@puc-rio.br.
Dalton transactions (Cambridge, England : 2003)
|November 2, 2023
概括
从水连体合成的新铜 (II) 复合物显示出作为抗癌剂的潜力. 这些化合物表现出稳定性并与人血清白蛋白结合,这表明进一步研究瘤细胞系活性.
科学领域:
- 无机化学 无机化学
- 药用化学 医学化学
- 材料科学 材料科学 材料科学
背景情况:
- 基于的药物是标准的癌症治疗方法.
- 铜 (II) 复合体提供了一个具有潜在优势的多目标替代方案.
- 已知酸连接物能形成生物活性金属复合体.
研究的目的:
- 合成和描述新的单核和双核铜 (II) 协调化合物.
- 研究合成复合物的结构和光谱特性.
- 评估复合物的与人血清白蛋白 (HSA) 的结合亲和力.
主要方法:
- 使用5-甲基沙利西二甲基-2-醇 (H2L) 连接物合成铜 (II) 复合物.
- 使用光谱技术 (固态和溶液) 进行结构性表征.
- 计算建模来评估HSA结合相互作用和能量.
主要成果:
- 成功合成和表征了两种新的铜 (II) 复合物:单核 (1) 和双核 (2).
- 综合体1有一个由联体和离子协调的Cu (II) 中心.
- 复合体2是1的二维形式,具有氧桥,在水性介质中表现出增强的稳定性.
- 通过结合实验理论方法,这两种复合物都被证明与HSA结合,具有不同的亲和力和结合点.
结论:
- 合成的铜 (II) 复合物在水性介质中是稳定的.
- 这些复合物显示出HSA结合的潜力,这是药物输送的关键因素.
- 这些新型铜II) - 水复合物需要进一步研究它们对抗癌细胞系的抗增殖活性.
相关概念视频
02:58Crystal Field Theory - Octahedral Complexes
26.6K
Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
26.6K
02:42Valence Bond Theory
8.6K
Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
8.6K
03:02Colors and Magnetism
11.7K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
11.7K
02:34Structural Isomerism
19.2K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
19.2K
02:51Metal-Ligand Bonds
20.8K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
20.8K