在中国人口中,儿童和成年人之间的门息肉的差异
Yanyi Tu1, Tianjiao Jiang1, Yisha Wu1,2
1Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China.
The Laryngoscope
|November 2, 2023
概括
与儿童相比,成年人患有门息肉 (ACP) 显示出明显的临床和免疫病理差异. 成年非洲人中较高的IL-8和MMP-9水平可能表明更严重的组织重塑.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫病理学 免疫病理学
- 儿科耳鼻喉科 儿科耳鼻喉科
背景情况:
- 安特罗阿纳尔多 (ACP) 是一种良性鼻瘤.
- 了解与年龄相关的非洲和非洲国家之间的差异对于有针对性的治疗至关重要.
研究的目的:
- 调查中国儿童和成人患有ACP的患者之间的临床和免疫病理变异.
- 为了比较不同年龄组的ACP组织中的细胞因子和矩阵金属蛋白酶 (MMP) 水平.
主要方法:
- 对69名非洲和非洲国家患者的临床数据进行了追溯分析.
- 定量实时聚合酶连锁反应 (qPCR) 对于细胞因子和MMP-9 mRNA表达.
- 免疫光染色和西部斑点用于MMP-9蛋白质水平.
主要成果:
- 成年人 (n=18) 的性别比率与儿童 (n=51) 不同.
- Septal 偏差在成年人中更常见.
- 与儿童相比,在成年ACP组织中观察到显著更高的IL-8 mRNA和MMP-9 (mRNA和蛋白质) 水平.
结论:
- 成人和儿科ACP患者表现出不同的并发症和免疫病理学特征.
- 成年非洲人中IL-8和MMP-9的升高表明在更严重的组织重塑中发挥了作用.
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