瘤学中的效率-有效性差距:超越生存率
Brooke E Wilson1,2, Timothy P Hanna1,2, Christopher M Booth1,2
1Department of Oncology, Queen's University, Kingston, Ontario, Canada.
Cancer
|November 2, 2023
概括
疗效与有效性 (EE) 差距表明,临床试验与现实实践之间的治疗结果有所不同. 这种差距影响了生存,生活质量和成本,影响了医疗保健决策.
科学领域:
- 医疗保健服务研究 医疗服务研究
- 临床试验 临床试验
- 相对的有效性比较
背景情况:
- 有效性-有效性 (EE) 差距突出了对照临床试验结果和现实患者结果之间的差异.
- 这种差距传统上侧重于生存差异,可能会忽视其他关键患者和系统影响.
研究的目的:
- 扩大对超出生存结果的EE差距的理解.
- 强调在治疗决策中考虑生活质量,毒性,成本效益和患者时间的重要性.
主要方法:
- 审查现有证据在各种领域的EE差距.
- 评论这些差距对患者,临床医生和医疗保健系统的影响.
主要成果:
- 证据支持EE在生活质量,时间毒性和成本效益方面的差距存在.
- 这些更广泛的EE差距可能导致对治疗效益的不切实际期望.
结论:
- EE差距不仅仅包括生存,影响生活质量,毒性和经济因素.
- 进一步的研究至关重要,以充分理解和解决这些多方面的EE差距,以便明智地做出临床和医疗保健政策决策.
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