新生儿具有先天性细胞巨乳病毒感染的自然听力演变的危险因素
Elise De Cuyper1, Frederic Acke1,2, Annelies Keymeulen3
1Department of Head and Skin, Ghent University, Ghent, Belgium.
JAMA otolaryngology-- head & neck surgery
|November 2, 2023
概括
遗传性细胞大脑病毒 (cCMV) 可以导致儿童的感觉神经听力损失. 这项研究发现,感染的时间影响了晚期发病的听力损失风险,强调了持续听力学随访的必要性.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 听力学 听力学是指听力学.
背景情况:
- 遗传性细胞大脑病毒 (cCMV) 是婴儿非遗传性神经传感性听力损失的主要原因.
- 目前用于识别有不良听力结果高风险的婴儿的标准有限.
研究的目的:
- 确定患有cCMV的婴儿听力改善,恶化和晚期听力损失的风险因素.
- 为了告知家长咨询和患者管理策略.
主要方法:
- 一项多中心队列研究分析了387名未经治疗的cCMV感染的新生儿的数据.
- 听力学随访至少进行了4年.
- 研究了包括妊娠特征,临床发现,病毒载量和血清转化时间在内的危险因素.
主要成果:
- 大多数耳朵 (90%) 保持了稳定的听力.
- 晚期发病的听力损失发生在6.3%的耳朵中,在第一季度感染的患病率更高.
- 过早生育与听力改善有关,而第三个三个月的血清转换显示没有晚期发病的听力损失.
- 在70.6%的耳朵中观察到听力恶化,这些耳朵先前有听力损失.
结论:
- 持续的听力学随访对于由于cCMV引起的先天性听力损失的儿童至关重要.
- 母体血清转换的时间与晚期听力损失的风险有关.
- 需要对治疗效果进行进一步的研究,并确定新的风险因素.
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