创伤后应激障碍症状和女性心血管和大脑健康
Rebecca C Thurston1,2,3, Karen Jakubowski1, Yuefang Chang4
1Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
JAMA network open
|November 2, 2023
概括
创伤后应激障碍 (PTSD) 与中年妇女的心血管问题和大脑健康问题有关. 患有PTSD和APOEε4基因的女性显示大脑小血管疾病和认知能力下降的增加.
科学领域:
- 神经科学是一个神经科学.
- 心血管健康 心血管健康
- 精神病学是一个精神病学.
背景情况:
- 创伤后应激障碍 (PTSD),心血管疾病 (CVD) 和阿尔茨海默病是严重的公共卫生问题,特别是对女性来说.
- 创伤后应激障碍对女性心血管和大脑健康的影响仍未得到充分研究.
研究的目的:
- 检查PTSD症状与动脉内膜介质厚度 (IMT),大脑白质超强度体积 (WMHV) 和中年女性的认知功能之间的关联.
- 研究APOEε4基因型在这些关联中的潜在修饰作用.
主要方法:
- 一项涉及274名中年女性 (45-67岁) 进行的横截面研究,这些女性以前没有心血管疾病,中风或痴呆症.
- 数据收集包括问卷 (PTSD检查清单-民用版本),身体测量,瘤手术,神经心理测试,大脑管道超声波和3特斯拉脑部MRI.
- 统计分析使用线性回归模型,通过APOEε4状态测试相互作用.
主要成果:
- 较高的PTSD症状与动脉IMT增加相关,表明较大的动脉动脉样硬化.
- 在APOEε4携带者中,PTSD症状与更大的WMHV (全脑,周周,深层和正面) 和在认知领域 (包括注意力,工作记忆,语义流性,感知速度和处理速度) 的表现较差显著相关.
结论:
- 较大的PTSD症状与中年妇女的动脉动脉样硬化的增加有关.
- 在携带APOEε4基因型的女性中,PTSD症状与大脑小血管疾病的增加和认知功能受损有关,突出显示了不良的心血管和神经认知影响.
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