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硫化和肝脏健康:关于肝脏疾病的见解

Thuy T P Nguyen^1,2, Phuc L Nguyen¹, So-Hyun Park³

¹Department of Animal Science, College of Agriculture and Life Science, Chonnam National University, Gwangju, Republic of Korea.

Antioxidants & redox signaling

|November 2, 2023

概括

硫化 (H2S) 是一种重要的气传递物,保护器官免受损伤. 本综述探讨了其在肝脏健康和NAFLD和癌症等疾病中的复杂作用,强调了治疗潜力.

科学领域:

生物化学生物化学
身体生理学身体生理学
肝病学肝病学是一种肝病学.

背景情况:

硫化 (H2S) 作为一种气体传递物,可以保护哺乳动物免受氧化应激,炎症,高血压和细胞死亡.
肝脏富含H2S生成酶,受到H2S信号的显著影响,肝脏的H2S来自肠道微生物群,外源和内源生产.
肝脏H2S在肝脏疾病中起着至关重要的作用,包括非酒精性脂肪性肝病 (NAFLD),肝损伤和癌症,缺陷与严重疾病有关.

研究的目的:

批判性地评估硫化 (H2S) 在肝脏生理学和病理学中的生产,新陈代谢,作用机制和各种作用.
综合目前对H2S参与非酒精性脂肪性肝病 (NAFLD),肝损伤和肝癌的理解.
探索向H2S通路用于肝病管理的治疗潜力.

主要方法:

关于硫化 (H2S) 在肝功能和疾病中的现有研究的文献审查和批判性分析.
对肝脏信号传递相关的内源和外源H2S的检查.
根据捐赠者类型,剂量,持续时间和细胞环境评估H2S的多面性作用和争论中的影响.

主要成果:

内源的H2S缺乏与恶化的肝病相关,而外源的H2S捐赠者则表现出对肝功能障碍的保护作用.
在NAFLD,肝损伤和癌症中H2S的确切作用是复杂的,取决于环境,受各种因素的影响.
H2S表现出对氧化应激,炎症和细胞死亡的保护功能,这与维持肝脏健康有关.

结论:

了解H2S在肝脏健康和疾病中的复杂机制对于推进治疗策略至关重要.
准H2S生成酶或利用外源H2S捐赠者为临床前和临床肝病干预提供了有前途的途径.
对内源H2S水平的量化可以作为诊断和管理肝病的有价值的生物标志物.

关键词:

这是NAFLD.纤维化纤维化肝细胞癌是肝细胞癌.硫化是硫化的一种物质.

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