老龄化减弱了运动增强的运动皮质可塑性
Dylan Curtin1, Claire J Cadwallader1, Eleanor M Taylor1
1The Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.
The Journal of physiology
|November 2, 2023
概括
高强度运动在年轻人中增加了运动皮层的可塑性,但在老年人中这种效果减少了. 老龄化似乎减少了大脑的功能.
科学领域:
- 神经科学是一个神经科学.
- 运动生理学 运动生理学
- 衰老研究研究 衰老研究
背景情况:
- 众所周知,心肺运动可以增强年轻成年人的运动皮质可塑性.
- 衰老对运动诱导的运动皮质可塑性的影响仍然在很大程度上未被探索.
研究的目的:
- 为了研究衰老对运动介导的运动皮质可塑性的影响.
- 为了比较高强度间歇运动对年轻人与老年人初级运动皮层可塑性的影响.
主要方法:
- 利用跨磁刺激 (TMS) 来测量20名年轻人和20名老年人的皮质刺激和抑制活性.
- 在20分钟高强度间歇自行车运动或休息之前和之后评估运动皮质可塑性,随后进行间歇性达爆发刺激 (iTBS).
主要成果:
- 在运动后,年轻人和老年人表现出增加的谷氨酸激活和减少的GABAergic抑制.
- 与年轻人相比,老年人表现出运动后对iTBS的可塑性反应减弱.
结论:
- 皮层可塑性显示出与年龄相关的下降.
- 与年轻人相比,高强度间歇运动可能在提高老年人初级运动皮层可塑性方面效果不佳.
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