肺炎菌株血清型16F系的基因组流行病学
Jolynne Mokaya1, Kate C Mellor1, Gemma G R Murray1,2
1Parasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.
Microbial genomics
|November 2, 2023
概括
在南非出现非疫苗血清型16F肺炎链球菌突出显示,需要更广泛的疫苗策略. 基因组监测对于跟踪血清型16F血统,它们的抗菌素耐药性和对全球健康的影响至关重要.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 肺炎链球菌仍然是一个全球性的健康问题,因为在接种疫苗的人群中出现了非疫苗血清型.
- 血清型16F是南非婴儿中占主导地位的非疫苗血清型,需要进一步表征.
研究的目的:
- 来自南非的血清型16F Streptococcus pneumoniae分离物的血统和抗菌耐药性的特征.
- 使用现有的基因组数据,将这些发现置于全球视角的背景中.
主要方法:
- 对来自南非婴儿的10923个S. pneumoniae载体分离物的基因组分析.
- 包括来自全球肺炎球菌测序项目 (全球49个国家,1995-2018) 的19607个S. pneumoniae分离物 (49个国家,1995-2018).
- 推断血清型,抗菌素耐药性概况和全球肺炎球菌序列集群 (GPSCs).
主要成果:
- 血清型16F占南非分离物的9%,全球分离物的2%.
- GPSC33和GPSC46是16F血清型最常见的血统,分别与携带和疾病有关.
- 在这些GPSC中,在10-18%的16F分离物中发现了对青素和co-trimoxazole的抗菌素耐药性基因,有证据表明新兴的耐药性基因系.
结论:
- 血清型16F系在南非普遍存在,其中一些与疾病和抗菌素耐药性有关.
- 建议进行持续的基因组监测,以监测16F对疫苗疗效的影响,并指导抗菌疗法.
- 开发提供针对更广泛的血清型/血统保护的疫苗至关重要.
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