在肉牛的顺序采样中,用于纵向特征的候选基因
Virgínia Mara Pereira Ribeiro1, Gabriela Canabrava Gouveia1, Fabio Luiz Buranelo Toral1
1Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
概括
确定肉牛体重的功能候选基因 (FCG) 受测量年龄和采样方法的影响. 基因DUSP10始终与所有年龄段的体重有关,这突显了它的重要性.
科学领域:
- 动物遗传学动物遗传学
- 量化遗传学 量化遗传学
- 基因组学就是基因组学.
背景情况:
- 测量年龄和预取样程序可以影响与肉牛特征相关的功能候选基因 (FCG) 的识别.
- 了解不同生长阶段对体重的遗传控制对于繁殖计划至关重要.
研究的目的:
- 确定参与肉牛五个不同年龄的体重遗传控制的FCG.
- 评估顺序采样对遗传参数估计和全基因组关联研究 (GWAS) 结果的影响.
主要方法:
- 在五个年龄段测量身体重量 (约. 330550天) 在肉牛群中.
- 用单特征 (STM) 和随机回归模型 (RRM) 估计了基因参数,并使用了两个数据库 (所有动物与最重的70%对比).
- 用21,667个SNP标记进行了全基因组关联研究 (GWAS),以确定基因组窗口并优先考虑FCG.
主要成果:
- 七个FCG与不同年龄段的体重有关,DUSP10被确定为所有五个年龄段的一致的FCG.
- 使用所有动物 (DB100) 估计的遗传参数在STM和RRM之间是相似的.
- 序列采样 (DB70) 导致遗传参数的差异,特别是在使用STM时,但不是RRM.
结论:
- 特定基因对动物生长的重要性可以随年龄而异,不同的基因在不同的生长阶段更相关.
- 顺序采样策略可以影响GWAS对肉牛体重等纵向特征的结果.
- 测量时间和预抽样方法可以在研究中在FCG识别中引入不一致性.
更多相关视频
07:46Author Spotlight: Improving Beef Cattle Nutrition and Production with a Focus on Feed Efficiency and Meat Quality Traits Through Advanced Biochemical and Molecular Assays
Published on: July 12, 2024
559
08:39Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing
Published on: September 1, 2017
7.6K
相关概念视频
01:43Incomplete Dominance
22.6K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
22.6K
02:05Gene Evolution - Fast or Slow?
7.1K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.1K
01:11Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K
01:49Hardy-Weinberg Principle
72.2K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
72.2K
02:51Multi-species Conserved Sequences
3.9K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
3.9K
01:18Dihybrid Crosses
75.0K
Overview
75.0K