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在前列腺放射治疗后,第二次原发性癌症的风险和预后

Elisa K Liu¹, Thomas B Daniels¹, Jonathan W Lischalk²

¹Department of Radiation Oncology, NYU Grossman School of Medicine, New York, New York.

Urology practice

|November 2, 2023

概括

前列腺癌的放射治疗可能会增加二次盆腔恶性瘤的风险,但绝对风险仍然很低. 发展为二次癌症会影响生存率,特别是在年轻患者中.

科学领域:

在瘤学瘤学.
辐射瘤学辐射瘤学
癌症流行病学癌症流行病学

背景情况:

前列腺癌的生存率正在改善,需要了解长期治疗副作用.
在前列腺癌治疗后发生二次癌症的风险,尤其是在老年人中,需要进一步调查.

研究的目的:

评估前列腺癌诊断后第二次原发性骨盆恶性瘤 (SPPMs) 的发生率.
评估放射治疗对SPPM发育和整体存活率的影响.

主要方法:

从1975年至2016年使用监测,流行病学和最终结果数据分析了569,167例前列腺癌病例.
使用了细灰竞争风险模型和时间变化的考克斯比例危险模型.
评估了SPPMs的风险和与死亡率的关联,控制了患者和治疗因素.

主要成果:

放射治疗与SPPMs的发病率较高有关 (1.8%与25年后的1.1%相比).
患有SPPM显著恶化了生存率 (aHR=1.76),特别是在63岁以下的患者中 (aHR=2.36).
在研究人群中,共发现了4956个SPPMs.

结论:

虽然放射治疗可能会增加SPPM风险,但绝对风险很低.
二次性恶性瘤会对整体存活率产生负面影响,对年轻患者的影响更为明显.

关键词:

前列腺辐射疗法前列腺辐射辐射诱导的癌症辐射诱导的癌症第二次恶性瘤.

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