低收入和中等收入国家的人类基因组合作研究中的数据共享实践:系统审查协议
Deborah Ekusai-Sebatta1, Moses Ocan2,3, Shenuka Singh4
1Department of Anatomy, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda.
PloS one
|November 2, 2023
概括
本系统性审查审查了全球基因组研究中的伦理数据共享,重点关注南北和南南合作. 它旨在确定低收入和中等收入国家公平数据共享实践的标准.
科学领域:
- 基因组学就是基因组学.
- 生物伦理学生物伦理学
- 健康 公平 卫生 公平
背景情况:
- 越来越大的基因组数据库是通过结合参与者数据来创建的.
- 资助者要求在新研究中共享数据,除非存在合理的理由.
- 获取基因组数据引发了伦理问题,影响了全球研究合作中的公平性.
研究的目的:
- 在人类基因组协作研究中系统审查数据共享实践.
- 突出在低收入和中等收入国家共享数据的伦理,法律和社会影响.
- 在国际基因组研究中建立公平共享数据的标准.
主要方法:
- 系统审查协议与PRISMA指南保持一致,在PROSPERO.中注册.
- 在多个数据库 (PubMed,Google Scholar,EMBASE,Web of Science,MEDLINE) 进行全面的文献搜索,包括灰色文献.
- 独立审稿人的数据提取和偏差风险评估,在可行的情况下使用叙事综合和元分析进行分析.
主要成果:
- 该审查将综合北南和南南基因组研究中数据共享背景的证据.
- 它旨在确定道德数据共享的挑战和最佳实践.
- 调查结果将为为LMICs开发数据共享标准提供信息.
结论:
- 本次审查将增强国际基因组研究数据共享的伦理,法律和社会影响的证据基础.
- 它旨在为公平的数据共享提供可操作的标准,特别是有利于LMICs.
- 向利益相关者传播将促进LMICs的充分覆盖和实施.
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