可NIR激活的异构结构纳米辅助剂CoP/NiCoP执行乳酸盐代谢干预措施,用于增强光催化疗法和光免疫疗法
Chunzheng Yang1,2, Jiashi Zhang1,2, Mengyu Chang3
1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Advanced materials (Deerfield Beach, Fla.)
|November 2, 2023
概括
这项研究引入了一种新的纳米辅助剂,通过向乳酸 (LA) 积累来打击瘤免疫逃避. 这种方法提高了近红外光免疫疗法的疗效,并减少了瘤生长和转移.
科学领域:
- 生物医学工程 生物医学工程
- 癌症免疫疗法癌症免疫疗法
- 纳米技术纳米技术
背景情况:
- 近红外 (NIR) 光免疫疗法显示出有希望的结果,但由于乳酸 (LA) 积累而受到免疫逃避的限制.
- 细胞内残留的LA促进瘤细胞的增殖,阻碍了治疗的有效性.
研究的目的:
- 开发一种免疫调节纳米辅助剂,同时缓解免疫抑制并增强抗瘤免疫力.
- 通过向瘤细胞代谢来解决NIR光免疫疗法的局限性.
主要方法:
- 构建了一个蛋黄CoP/NiCoP (CNCP) 异构纳米辅助剂,装载有化 (Flu),一种单碳酸转运体4抑制剂.
- 利用NIR照射激活CNCP进行光热和光催化作用.
- 调查了流感在抑制LA排泄中的作用,并将LA作为增强光催化剂的孔吸尘器.
主要成果:
- 在NIR照射下,CNCP表现出卓越的光热性能和光催化反应性氧物种和的光催化生产.
- 流感释放有效抑制了LA排泄,而耗尽的LA提高了光催化效率.
- 联合疗法启动了全身免疫反应,诱导了线粒体功能障碍,并破坏了能量供应,导致轻微的光热疗法效应.
结论:
- 通过CNCP-Flu纳米辅助剂进行乳酸代谢重塑,为强效,代谢调节的免疫疗法提供了一种新的策略.
- 这种方法有效地抑制瘤扩散和转移,具有最佳的安全性,为癌症治疗提供了一个新的范式.
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