患有I和II期结肠癌的患者的多变量预后模型:一个符合斯特罗布的回顾性队列研究
Luis F Oñate-Ocaña1, Roberto Herrera-Goepfert2, Alejandro Avilés-Salas2
1Clinical Research Subdirectorate, Mexico City, Mexico.
概括
结肠癌 (CC) I-II期的新预后模型确定了整体存活 (OS) 的关键因素. 这些简单的模型可以为CC患者指导治疗决策和临床试验设计.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床研究 临床研究
背景情况:
- 大肠直肠癌 (CRC) 是全球领先的胃肠道恶性瘤.
- 对于I和II阶段的CRC,辅助治疗的有效性仍在争论中.
- 准确的预后对于量身定制患者管理至关重要.
研究的目的:
- 开发和验证I-II阶段结肠癌 (CC) 的术后预后模型.
- 确定影响CC患者复发和生存的临床和组织病理因素.
- 在早期的CC中提供风险分层和治疗指导的工具.
主要方法:
- 在25年内对556名I-II期CC患者进行了回顾性队列研究.
- 随机分配到建模 (n=339) 和验证 (n=217) 组的患者.
- 对临床,遗传学和免疫组织化学因素的分析,包括CDX2和MUC2表达.
主要成果:
- 针对复发,无病生存期 (DFS) 和整体生存期 (OS) 开发了三种预后模型.
- 与OS相关的因素包括瘤位置,淋巴细胞和单细胞计数,中性粒细胞/血小板细胞比率,白蛋白/单细胞比率和微观残留疾病.
- 瘤分类 (T) 和CDX2/MUC2表达没有独立与复发或预后相关.
结论:
- 开发的模型是简单的,可访问的,并且具有成本效益,用于评估CC的I-II阶段的风险.
- 这些模型可以为辅助治疗与监测的决策提供信息.
- 这些模型可能有助于设计未来的早期结肠癌临床试验.
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