在入住ICU的265名危急COVID-19患者中,第一波和第二波之间的长期生存比较:回顾性队列研究
Nour-El-Imane Taghboulit1, Claire Andrejak2, Yazine Mahjoub3
1Department of Respiratory Disease and Critical Care Unit, University Hospital Centre Amiens-Picardie, Amiens, France 1, Rue du Professeur Christian Cabrol 80054 Amiens-Cedex, France.
Respiratory medicine and research
|November 2, 2023
概括
尽管COVID-19护理发生了变化,但在第二波期间入院的患者的长期存活率更差. 较高的SAPS II分数,年龄较大和第二波入院预测严重的COVID-19患者的结果较差.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 在重症监护室 (ICU) 严峻的COVID-19患者管理在大流行初期的几个月里显著发展.
- 关于这些不断变化的管理策略对重症COVID-19患者的长期生存的影响仍然存在不确定性.
研究的目的:
- 为了比较严重的COVID-19患者的长期存活率在第一波和第二波的流行病期间入院到ICU.
- 为了确定这一重症患者队列中长期生存的预测因素.
主要方法:
- 进行了一项回顾性队列研究,涉及2020年2月至2021年1月期间入住法国ICU的COVID-19肺炎成年患者.
- 主要结局是比较第一波和第二波大流行期间的长期存活率.
- 考克斯的比例风险模型被用来确定生存预测因素.
主要成果:
- 该队列包括265名患者 (第一波140名,第二波125名).
- 第二波看到了早期皮质疗法和高流氧疗法的使用增加,侵入性机械通风减少,以及更短的ICU停留时间.
- 集中治疗室的死亡率在各个波段之间相似 (32.8%),但生存分析发现,较高的SAPS II分数,较高的年龄和第二波入院是较差的长期预后的独立预测因素.
结论:
- 尽管严重的COVID-19患者管理发生了变化,但在第二波期间入院的患者的长期存活率下降.
- 在第二波疫情中,ICU停留时间也较短.
- 年龄,SAPS II分数和入院波显著影响了长期生存结果.
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