含硫氨基酸与精神分裂症的风险
Xue Wu1, Huaixuan Ao1, Xiaoyong Wu2
1Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550025, China; The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550003, China.
Schizophrenia research
|November 2, 2023
概括
这项研究发现,同型半氨酸 (Hcy),半氨酸 (Cys) 和氨酸 (Met) 的水平与精神分裂症风险有关,并观察到基于性别的显著差异. 这些含硫的氨基酸可能在精神分裂症的发展中起作用.
科学领域:
- 生物化学 生物化学
- 精神病学是一个精神病学.
- 代谢学 代谢学 代谢学
背景情况:
- 精神分裂症是一种严重的精神疾病,男性和女性之间存在不同的风险.
- 含硫的氨基酸,包括homocysteine (Hcy),cysteine (Cys) 和methionine (Met),对于新陈代谢至关重要,可能会影响精神分裂症的发病.
研究的目的:
- 调查血液中Hcy,Cys和Met的水平与精神分裂症风险之间的关联.
- 评估这些关联中的潜在性别特异性差异.
主要方法:
- 一项涉及876名精神分裂症患者和913名健康对照者的病例控制研究.
- 使用液体染色学-并联质谱法对Hcy,Cys和Met进行量化.
- 使用受限立方线和测试性相互作用的协会分析.
主要成果:
- 低水平的homocysteine (Hcy) (≤29μmol/L) 和高水平的methionine (Met) (≤22μmol/L) 与分别增加和减少精神分裂症风险有关.
- 升高的氨酸 (Cys) 水平与精神分裂症风险降低相关.
- 在氨基酸水平和性别之间发现了显著的协同作用.
结论:
- 含硫氨基酸与精神分裂症密切相关,男性和女性有不同的风险概况.
- 需要进一步的研究来阐明Hcy,Cys和Met在精神分裂症中的特定致病作用.
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