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在猫类皮肤状细胞癌中改变了E-cadherin/β-catenin表达

Berenice L Sanz Ressel¹, Gimena Gomez Castro¹, Adriana R Massone²

¹Laboratorio de Histología y Embriología Descriptiva, Experimental y Comparada, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118, ZC 1900, La Plata, Buenos Aires, Argentina; Facultad de Ciencias Veterinarias, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de La Plata, Calle 60 y 118, ZC 1900, La Plata, Buenos Aires, Argentina.

Journal of comparative pathology

|November 2, 2023

概括

改变E-cadherin和β-catenin的表达在猫类皮肤状细胞癌 (CSCC) 中很常见. 这些分子变化表明在癌症的发展和一些猫类CSCC病例中潜在的Wnt途径参与中发挥了作用.

科学领域:

兽医病理学兽医病理学
分子瘤学分子瘤学
皮肤病学皮肤病学

背景情况:

皮肤状细胞癌 (CSCC) 是猫科动物中最常见的皮肤恶性瘤.
驱动猫类CSCC的潜在分子机制在很大程度上仍未被描述.
对E-cadherin和β-catenin的失调与人类和狗的CSCC有关.

研究的目的:

为了研究猫类CSCC中E-cadherin和β-catenin的表达模式.
为了确定这些蛋白质是否在猫类皮肤瘤中失调.
探索它们在猫科动物CSCC病变发生过程中的潜在作用.

主要方法:

对43只猫科动物的CSCC组织样本进行免疫组织化学分析.
使用组织微阵列来有效评估样本.
评估E-cadherin和β-catenin的局部化 (膜,细胞质,核).

主要成果:

在CSCC样本中观察到显著减少E-cadherin的膜表达.
在猫科动物的CSCC中观察到β-catenin的膜和细胞质表达减少.
在一组瘤中检测到异常的细胞质E-cadherin和核β-catenin表达.

结论:

改变的E-cadherin和β-catenin表达是猫类CSCC的频繁发现.
这些分子变化可能有助于猫类CSCC恶性表型的发展.
猫类CSCC的一个子集可能涉及Wnt途径的致癌.

关键词:

粘附分子的粘附分子猫猫猫在线观看皮肤状细胞癌瘤分子目标是分子目标.信号分子的信号分子.皮肤皮肤皮肤

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