在使用贝叶斯模型选择的初级大中央切口器中,对甲发育缺陷的预测者
Susan G Reed1, Sijian Fan2, Carol L Wagner1
1Department of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, Charleston, South Carolina, USA.
Caries research
|November 2, 2023
概括
孕前母亲的BMI,孕期因素和维生素D缺乏影响孩子的面膜发育. 了解这些暴露组变量有助于预防牙面膜发育缺陷 (DDE).
科学领域:
- 儿科牙科 儿科牙科
- 环境健康 环境健康
- 发展生物学 发展生物学
背景情况:
- 牙面膜 (DDE) 的发育缺陷包括牙面膜低成形 (EH),不透明 (OP) 和爆发后破坏 (PEB).
- 了解DDE的病因对于预防策略至关重要.
- 主要上中央切口在子宫和产后早期矿化.
研究的目的:
- 评估在初级大中切口发育过程中暴露组变量和DDE之间的关系.
- 为了确定质低成形,不透明和喷发后分解的关键预测因素.
主要方法:
- 利用现有的母婴双数据集,从孕期到婴儿早期.
- 对DDE结果分析了爆发的第一大中央切口的数字图像.
- 应用贝叶斯模型和吉布斯变量选择来识别重要的预测因素.
主要成果:
- 确定了关键预测因素:母亲怀孕前的BMI,母亲的血清和,孩子的妊娠年龄,以及母亲和孩子的功能维生素D缺乏 (FVDD).
- 对OP的重要预测因素:妊娠年龄>36周和出生时的FVDD.
- 对PEB的显著预测因素:母亲怀孕前的BMI<21.5和28周的血清含量较高.
结论:
- 该研究为评估牙发育过程中的及时生物标志物测量提供了一个框架.
- 确定了影响DDE的特定母婴因素.
- 结果可以为未来的DDE.DE预防策略提供信息.
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