人工甜味剂-酸盐消费与结肠直肠癌风险之间的关联:基于证据的策略
Chenglou Zhu1,2,3, Dandan Ji2, Jichun Ma1,2,3
1The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Oncology
|November 2, 2023
概括
人造甜味剂 (ASs) 可能会降低结肠直肠癌 (CRC) 的发生率,特别是在低剂量时. 这次元分析发现,AS摄入量与CRC死亡率之间没有显著的关联.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 人工甜味剂 (AS) 是广泛使用的糖替代品.
- 人们担心它们对癌症风险,特别是结直肠癌 (CRC) 的潜在影响.
- 之前的研究对AS摄入量和CRC之间的关联产生了相互矛盾的结果.
研究的目的:
- 系统地评估人工甜味剂消费与结直肠癌发病率和死亡率之间的相关性.
- 通过元分析综合来自多项临床试验的证据.
主要方法:
- 对来自10项研究 (三个病例控制,七个队列) 的数据进行了全面的元分析,涉及711,537名参与者.
- 在主要数据库中进行搜索,包括PubMed,Web of Science,Embase,MEDLINE和Cochrane图书馆,直到2023年7月24日.
- 使用STATA软件 (版本12.0) 的统计分析评估了AS暴露和CRC结果的几率比率 (ORs) 和95%置信区间 (CI).
主要成果:
- 总体而言,AS摄入与CRC发病率降低有关 (OR = 0.93,95% CI = [0.87-0.99]).
- 低剂量的AS消费与较低的CRC发病率有显著的关联 (OR = 0.90,95%CI = [0.83-0.99]).
- 在AS摄入量和CRC死亡率之间没有发现显著的关联 (OR = 0.93,95%CI = [0.83-1.05]).
结论:
- 低摄入人工甜味剂可能与患结直肠癌的风险降低有关.
- 目前的证据不支持人工甜味剂消费与CRC死亡风险增加之间的显著联系.
- 进一步的研究可能是有必要的,以阐明剂量特定的影响和长期影响.
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