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Updated: Jul 11, 2025

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可访问的高通量单细胞全基因组测序与配对染色质可访问性

Konstantin Queitsch1, Travis W Moore2, Brendan L O'Connell3

  • 1Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA.

Cell reports methods
|November 2, 2023
PubMed
概括

我们使用现有的ATAC-seq工作流程开发了一种新的,可访问的单细胞全基因组测序 (scWGS) 方法. 这种技术可以实现高通量拷贝数分析,并降低研究细胞基因组学的研究人员的成本.

关键词:
CP: 生物技术 生物技术科普:遗传学 在CP:遗传学.癌症生物学 癌症生物学染色质可访问性 染色质可访问性副本编号的变化 副本编号的变化单细胞基因组学 单细胞基因组学

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Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
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