纳米注射pH/NIR响应水凝用于化学-光热协同药物输送
Qian Zhao1, Xu Yue1, Liu Miaomiao2
1Key Laboratory of Functional Polymer Materials of MOE, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China.
Journal of biomaterials applications
|November 2, 2023
概括
一种新的智能水凝结合了化疗和光热疗法,以获得更安全,最少侵入性的癌症治疗. 这种pH/NIR双反应材料提供了增强的药物递送和瘤细胞破坏,并改善了生物相容性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 传统的癌症治疗通常具有高毒性和有限的疗效.
- 发展更少有毒和最少侵入性的治疗策略至关重要.
- 智能水凝为向药物输送和局部治疗提供了潜在的潜力.
研究的目的:
- 制造一个pH/近红外 (NIR) 双响应,纳米可注射的智能水凝用于癌症治疗.
- 开发一种安全有效的药物输送系统,用于协同化学光热疗法.
- 为增强瘤治疗创造一种最少的侵入性材料.
主要方法:
- 从N-异甲胺 (NIPAM) 和乌拉共聚合物制造水凝,其中包括硫化铜 (CuS) 纳米粒子.
- 使用TEM,SEM,NMR和FT-IR进行表征,以确认微观结构和特性.
- 在纳米凝中封装多克索鲁比辛 (DOX),然后加载CuS纳米颗粒,用于等级化药物输送系统.
主要成果:
- 水凝通过 uracil 的氨基组和通过 PNIPAM 的温度响应在 37°C 的 in situ 凝显示出 pH 响应.
- CuS纳米粒子使NIR光转化为热,增强了瘤细胞的破坏.
- 纳米复合物水凝表现出有希望的组织生物相容性和有效的体外化疗-光热协同疗法.
结论:
- 开发的智能水凝平台是一种安全有效的药物载体,用于联合化疗和光热疗法.
- 该材料通过局部药物释放和高热来促进最小侵入性瘤治疗.
- 这种双响应的水凝显示了高级癌症治疗的巨大潜力.
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