[针对晚期甲状腺癌的全身疗法 - 更新]
Tim Brandenburg1,2, Yara Maria Machlah1,2, Dagmar Führer-Sakel1,2
1Klinik für Endokrinologie, Diabetologie und Stoffwechsel, Universitätsklinikum Essen, Essen, Germany.
Deutsche medizinische Wochenschrift (1946)
|November 2, 2023
概括
四种多酶抑制剂 (MKI) 在德国治疗晚期甲状腺癌. 最近的批准包括Cabozantinib用于放射性耐火DTC和Selpercatinib用于MTC和DTC,提供新的向治疗选择.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 在德国,四种多酶抑制剂 (MKI) 已被批准用于治疗进展性放射性耐火的分化甲状腺癌 (rrDTC) 和髓性甲状腺癌 (MTC).
- 卡博桑提尼布最近获得批准,作为基于COSMIC-311试验的高级rrdTC的二线治疗.
- 塞尔珀卡提尼布是第一个批准的选择性RET抑制剂,在先进的MTC和rrDTC中显示出有效性.
研究的目的:
- 要总结最近在治疗晚期甲状腺癌 (ATC) 的进展.
- 为突出针对特定甲状腺癌亚型的新批准的向疗法.
- 为ATC提供当前治疗策略和指导方针的概述.
主要方法:
- 对已批准的多酶抑制剂进行III期临床研究的审查.
- 对Cabozantinib随机化COSMIC-311试验的数据分析.
- 评估Selpercatinib在高级MTC和 rrDTC中的疗效和副作用概况.
主要成果:
- 卡博赞提尼布已被批准作为高级rrdtc的二线治疗.
- 塞尔珀卡提尼布在一线高级MTC与RET突变和二线rrdTC与RET融合中表现出有希望的疗效.
- 与其他治疗方法相比,塞尔珀卡提尼布的副作用较少.
结论:
- 晚期甲状腺癌的治疗领域已经扩大,包括新的向疗法.
- 选择性RET抑制剂如Selpercatinib为特定患者群体提供了有效的选择.
- 当前的ATA指南反映了这些变化和ATC的新治疗方法.
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