肠道高水平的异黄素是食物过敏的潜在危险因素,通过调节树突细胞中的mTOR/AKT通路
Chong Wang1, Yanbo Wang1, Fangting Wang1
1Food Safety Key Laboratory of Zhejiang Province, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.
这项研究表明,高摄入异黄素可能会通过影响肠道微生物群和树突细胞活动来加剧食物过敏. 减少饮食中的异黄素可能是管理食物过敏的策略.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 食物过敏是一个日益严重的全球健康问题,特别是在工业化地区.
- 导致食物过敏易感增加的确切机制尚不清楚.
研究的目的:
- 研究益生菌Lactobacillus casei Zhang (LcZ) 在调节过敏反应中的作用.
- 探索肠道异黄素代谢,肠道微生物群和食物过敏之间的联系.
- 阐明涉及异黄素介导过敏反应的分子途径.
主要方法:
- 向过敏个体施用LcZ,并分析与过敏相关的因素.
- 超基因组分析,以确定肠道异黄素的来源.
- 使用食物过敏的小鼠模型来评估高异黄素饮食的影响.
- 使用树突细胞模型与蛋白质阵列和分子对接来识别分子点.
主要成果:
- 使用LcZ缓解了过敏反应.
- 在肠道异黄素水平和免疫球蛋白E (IgE) 度之间发现了显著的相关性.
- 肠道微生物群的新陈代谢被确定为异黄素的来源.
- 在小鼠中,高含异黄素的饮食加剧了过敏反应和树突细胞活性.
- mTOR/AKT通路和Sestrin2参与了异黄素的功能.
结论:
- 肠道异黄素在促进食物过敏方面发挥着作用.
- 肠道微生物群对异黄素的可用性有显著的贡献.
- mTOR/AKT通路调解了异黄素对过敏反应的影响.
- 摄入高的异黄素可能是发展食物过敏的危险因素.
更多相关视频
06:57Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
Published on: September 18, 2016
09:04DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
相关概念视频
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Renewal of Intestinal Stem Cells
PI3K/mTOR/AKT Signaling Pathway
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
