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PCB126通过影响翻译后的修饰和线粒体功能,损害人类精子功能

Yebin Yang¹, Guangquan Mei², Liu Yang¹

¹College of Chemistry and Biological Engineering, Yichun University, Yichun, China.

|November 2, 2023

概括

环境污染物PCB126对人类精子功能产生负面影响. 这项研究研究了PCB126的研究.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
生殖生物学生殖生物学

背景情况:

全球精液质量下降与环境污染有关.
持久性有机污染物 (POP),如多二 (PCB),是环境污染物.
PCB126是一种具有潜在健康危害的内分泌干扰化学物质,但其对人类精子功能的影响尚不清楚.

研究的目的:

研究PCB126对人类精子运动性,活力,过度活化和体反应的影响.
阐明PCB126引起的人类精子功能障碍背后的分子机制.
检查PCB126对精子中关键蛋白质修饰和线粒体功能的影响.

主要方法:

人类精子在体外暴露在PCB126 (0.0110μg/mL) 的不同度下,1到2小时.
评估精子的运动性,活力,过度活化和体反应.
分析蛋白质修饰 (铁酸化,酸化) 和线粒体参数 (ROS,MDA,MMP,ATP生成) 的分析.

主要成果:

暴露于PCB126对人类精子的运动性,活力,过度活化和体反应产生了负面影响.
PCB126干扰了关键的翻译后修改,包括氨酸酸化和氨酸质化.
线粒体功能受损,由改变的ROS,MDA水平,线粒体膜潜力和ATP生成所证明.

结论:

在体外接触PCB126会对人类精子功能产生不利影响.
PCB126通过干扰转化后修饰和线粒体通路来破坏精子功能.
研究结果强调了像PCB126这样的环境污染物对男性生殖健康的有害影响.

关键词:

3,3′,4,4′,5-pentachlorobiphenyl是什么意思 3,3′,4,4′,5-pentachlorobiphenyl是什么意思 3,3′,4,4′,5-pentachlorobiphenyl是什么意思 3,3′,4,4′,5-pentachlorobiphenyl是什么意思 3,3′,4,4′,5-pentachlorobiphenyl是什么意思 3,3′,4,4′,5-pentachlorobiphenyl是什么意思线粒体功能障碍线粒体功能障碍后翻译修改后的修改.有反应性氧物种的反应性氧物种.人类精子的人类精子

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