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Updated: Jul 11, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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什么能增强蛋白质与蛋白质之间的相互作用:残余相关性网络的分析和应用

Ta I Hung1, Yun-Jung Hsieh2, Wei-Lin Lu3

  • 1Department of Chemistry, University of California, Riverside, United States; Department of Bioengineering, University of California, Riverside, United States.

Journal of molecular biology
|November 2, 2023
PubMed
概括

设计强效的蛋白质结合剂需要了解残留物相互作用. 这项研究揭示了如何突变乌比基中的相关残留物增强了对MERS PLpro的结合亲和力,从而创造了有效的治疗候选者.

关键词:
二面角对应网络的二面角对应网络.纳米分子粘合剂的使用帕帕因类蛋白酶是一种类似帕帕因的蛋白酶.基于蛋白质的抑制剂 基于蛋白质的抑制剂无处不在的变种.

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