用基酸盐/甲基基和氨酸对聚乙烯的表面进行修改,以实现抗凝作用
Yongqi Zhang1, Jia Man1, Jiali Wang2
1Key Laboratory of High Efficiency and Clean Mechanical Manufacture of Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, PR China; Key National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, PR China.
International journal of biological macromolecules
|November 2, 2023
概括
研究人员开发了先进的肝素化表面,以防止医疗器械中的血栓形成. 这种新的方法增强了抗凝固特性和血液兼容性,为直接注射抗凝固剂提供了更安全的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 表面化学 表面化学
- 医疗器械技术 医疗器械技术
背景情况:
- 身体外电路中的血栓形成是致病率和死亡率的主要原因.
- 直接注射抗凝剂可能会导致显著的副作用.
研究的目的:
- 在PVC基板上使用等离子体处理和化学接种来开发化表面.
- 改善医疗器械表面的抗凝固特性和血液兼容性.
- 为了减少血栓形成的发生率和与抗凝剂相关的副作用.
主要方法:
- 使用等离子体处理对PVC基板进行了修改,以产生活性基.
- 通过各种策略,氨酸被移植到修改后的PVC表面上.
- 藻酸盐 (SA) 和甲基基 (CCS) 被用作中间层来增强肝素移植.
- 低分子量肝素 (LWMH) 用于表面修饰.
主要成果:
- SA和CCS的中间层显著增加了肝素移植密度,并改善了抗凝剂作用.
- 碳氧甲基基托桑/低分子量肝素 (CCS/LWMH) 表面表现出优异的抗凝固特性.
- 该CCS/LWMH表面延长了激活的部分血栓形成时间 (APTT) 大约35秒.
- 血液溶解率降低到0.3%以下,这表明血液兼容性很好.
- 实验室血液循环测试证实了肝素化表面的有效性.
结论:
- 使用等离子处理和化学移植制造的肝素化表面显示出医疗器械的巨大潜力.
- 使用SA和CCS中间层有效地提高了氨酸接种和抗凝剂性能.
- CCS/LWMH表面为减少体外电路中的血栓形成提供了一个有希望的解决方案.
- 这项技术为全身抗凝剂治疗提供了更安全的替代方案.
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