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在SERCA调节剂myoregulin中用阿斯巴拉金取代Lys27:一个Ca2+亲和力调节器或催化活性开关?

Nishadh Rathod1, Guadalupe Guerrero-Serna2, Howard S Young1

  • 1Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.

Biochimica et biophysica acta. Molecular cell research
|November 2, 2023
PubMed
概括

肌红素 (MLN) 增强了质网膜的Ca2+-ATPase (SERCA) 抑制. 用Asn取代Lys27可以增加MLN的功效,而不会改变SERCA Ca2+亲和力,从而揭示了一个关键的调节部位.

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